8 research outputs found

    New genetic loci link adipose and insulin biology to body fat distribution.

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    Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

    Multi-Agent Role Allocation: Issues, Approaches, and Multiple Perspectives

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    In cooperative multi-agent systems, roles are used as a design concept when creating large systems, they are known to facilitate specialization of agents, and they can help to reduce interference in multi-robot domains. The types of tasks that the agents are asked to solve and the communicative capabilities of the agents significantly affect the way roles are used in cooperative multi-agent systems. Along with a discussion of these issues about roles in multi-agent systems, this article compares computational models of the role allocation problem, presents the notion of explicitly versus implicitly defined roles, gives a survey of the methods used to approach role allocation problems, and concludes with a list of open research questions related to roles in multi-agent systems
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